That is the view of former Hoops forward Charlie Nicholas, who says he feels the Parkhead atmosphere will be vital once again.
Brendan Rodgers’ men made it through to the last-32 of the Europa League by the skin of their teeth after RB Leipzig did them a late favour on matchday six.
But the Scottish champions were then handed a tough draw against La Liga competition in the first knockout round.
The Spanish team have gradually improved throughout the season and performed admirably against Manchester United in two Champions League games before Christmas.
But Nicholas thinks that his former team can take a first-leg lead to Spain if they stop Valencia’s danger man in Parejo.
“I am going with my heart over my head,” he told Sky Sports. “Celtic do not convince you in Europe.
“There are two special places in Britain for European nights, Anfield and Celtic Park.
“These are the nights where there is an extra edge, the Celtic fans turn up for it.
“I am going with my heart over my head”
“Valencia are eighth in La Liga and are a bit inconsistent going forward. They beat Manchester United at home and should have done away too.
“Daniel Parejo is a creative and silky midfield player – Celtic must stop him.
“Valencia can rely on the defence and sit in. Celtic must take an advantage going back to Valencia.
“When I see Rodrigo and Kevin Gameiro, they have serious fire-power. This team is very good at counter-attack football.
“Celtic have to keep their heads and be patient for the right moments. If they can stop Parejo and be aggressive, then I can see something happening.
“Oliver Burke has been good and is scoring goals, so he could be in the thick of it, but I am not totally convinced in this one.”
And Nicholas thinks that Celtic will win the first-leg 2-1.