After taking the lead through Ruben Loftus-Cheek, Chelsea conceded twice in four second-half minutes.
Sarri rotated his team, among five changes he rested Jorginho and brought Cesc Fabregas into the centre of midfield.
But the Italian once again chose to deploy N’Golo Kante on the right-hand side of a midfield trio, rather than his natural holding position.
Chelsea’s defeat saw them slip to 4th in the Premier League table, a full 10 points behind leaders Manchester City.
And Sarri seemed to point the finger at his players rather than absorbing the blame himself.
“I think we played very well for 55 minutes,” Sarri said.
“After the first [Wolves] goal – that was an accident because we were in full control of the match – we were suddenly another team, without the right distances, without our football.
“I don’t know why. I am really worried not for the result but for the fact that we didn’t react to the first goal of the opponent.
“I think it’s more important to talk about our attitude after the first goal.
“We were not the same team as before. So I don’t want to discuss if there was a foul on Willian or not.
“It’s not important for me. Maybe it was for the result, but not for me. I have to understand why the team was suddenly another team.”
Loftus-Cheek was one of the few Chelsea players to emerge from the game with any credit.
The England international opened the scoring with his fifth goal in his last nine games.
But the midfielder admitted that the Blues played in a sloppy fashion after the interval.
“We felt in control first half, felt comfortable and were playing some good football,” he said.
“But they came out fast second half and we were sloppy as a team. In the Premier League, if you’re sloppy you pay for it and that’s what happened.”